Now why would anyone want to do an enema, let alone a coffee enema? Well. . . Coffee enemas are used routinely in the process of detoxification to stimulate the liver, control pain, nausea, general nervous tension and depression. To make enemas the most effective, the patient should lie on their right side with both legs drawn up close to the abdomen. . .The caffeine is absorbed from the fluid within ten minutes through the hemorrhoidal veins directly and is then transported directly through the portal veins and into the liver. This stimulates the production of bile and gets that elimination system moving.